Dibenamine hydrochloride

CAS No. 55-43-6

Dibenamine hydrochloride ( N-?(2-?Chloroethyl)?dibenzylamine hydrochloride )

Catalog No. M28152 CAS No. 55-43-6

Dibenamine hydrochloride is a competitive and irreversible blocking agent of the β-adrenergic receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Dibenamine hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Dibenamine hydrochloride is a competitive and irreversible blocking agent of the β-adrenergic receptor.
  • Description
    Dibenamine hydrochloride is a competitive and irreversible blocking agent of the β-adrenergic receptor.(In Vitro):Dibenamine hydrochloride (100 nM-10 μM) attenuates the extent of cocaine-induced increases in sensitivity to acetylcholine, furthermore, the extent of diphenylamine-induced inhibition depends on the concentration of diphenylamine, which is inversely proportional to the concentration of cocaine. Dibenamine hydrochloride did not have any effect on acetylcholine contraction of isolated guinea-pig vas deferens .(In Vivo):Dibenamine hydrochloride causes a significant increase in the rate of destruction of L-epinephrine in the mouse. Pretreatment with Dibenamine hydrochloride apparently slowed the conversion of Ccl4 to CHCL3. Dibenamine hydrochloride (25 mg/kg; s.c.) decreased the CHCl3, levels at 2 and 6 hr by 30%-50%.
  • Synonyms
    N-?(2-?Chloroethyl)?dibenzylamine hydrochloride
  • Pathway
    Angiogenesis
  • Target
    Adrenergic Receptor
  • Recptor
    Akt;AP-1;COX;HO-1;MAPK;NF-κB;NO;NOS;Nrf2;p65;PDGFR;PGE;ROS;TNF-α
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    55-43-6
  • Formula Weight
    296.2
  • Molecular Formula
    C16H19Cl2N
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.ClCCN(Cc1ccccc1)Cc1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wu XD, et al. Bioactive sesquiterpenoids from the flowers of Inula japonica. Phytochemistry. 2016 Sep;129:68-76.
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