Dibenamine hydrochloride ( N-?(2-?Chloroethyl)?dibenzylamine hydrochloride )

Catalog No. M28152 CAS No. 55-43-6

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Product Name

Dibenamine hydrochloride
Note

Research use only, not for human use.
Brief Description

Dibenamine hydrochloride is a competitive and irreversible blocking agent of the β-adrenergic receptor.
Description

Dibenamine hydrochloride is a competitive and irreversible blocking agent of the β-adrenergic receptor.(In Vitro):Dibenamine hydrochloride (100 nM-10 μM) attenuates the extent of cocaine-induced increases in sensitivity to acetylcholine, furthermore, the extent of diphenylamine-induced inhibition depends on the concentration of diphenylamine, which is inversely proportional to the concentration of cocaine. Dibenamine hydrochloride did not have any effect on acetylcholine contraction of isolated guinea-pig vas deferens .(In Vivo):Dibenamine hydrochloride causes a significant increase in the rate of destruction of L-epinephrine in the mouse. Pretreatment with Dibenamine hydrochloride apparently slowed the conversion of Ccl4 to CHCL3. Dibenamine hydrochloride (25 mg/kg; s.c.) decreased the CHCl3, levels at 2 and 6 hr by 30%-50%.
Synonyms

N-?(2-?Chloroethyl)?dibenzylamine hydrochloride
Pathway

Angiogenesis
Target

Adrenergic Receptor
Recptor

Akt;AP-1;COX;HO-1;MAPK;NF-κB;NO;NOS;Nrf2;p65;PDGFR;PGE;ROS;TNF-α
Research Area

——
Indication

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1.Wu XD, et al. Bioactive sesquiterpenoids from the flowers of Inula japonica. Phytochemistry. 2016 Sep;129:68-76.

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